Cargando…
Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent
Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated peptides), complement activation (C5a), and subsequently through activation of leukocytes (e.g., leukotriene B4, platel...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213298/ https://www.ncbi.nlm.nih.gov/pubmed/14993252 http://dx.doi.org/10.1084/jem.20031636 |
_version_ | 1782148866221539328 |
---|---|
author | de Haas, Carla J.C. Veldkamp, Karin Ellen Peschel, Andreas Weerkamp, Floor Van Wamel, Willem J.B. Heezius, Erik C.J.M. Poppelier, Miriam J.J.G. Van Kessel, Kok P.M. van Strijp, Jos A.G. |
author_facet | de Haas, Carla J.C. Veldkamp, Karin Ellen Peschel, Andreas Weerkamp, Floor Van Wamel, Willem J.B. Heezius, Erik C.J.M. Poppelier, Miriam J.J.G. Van Kessel, Kok P.M. van Strijp, Jos A.G. |
author_sort | de Haas, Carla J.C. |
collection | PubMed |
description | Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated peptides), complement activation (C5a), and subsequently through activation of leukocytes (e.g., leukotriene B4, platelet-activating factor, and interleukin 8). Here we describe a new protein secreted by Staphylococcus aureus that specifically impairs the response of neutrophils and monocytes to formylated peptides and C5a. This chemotaxis inhibitory protein of S. aureus (CHIPS) is a 14.1-kD protein encoded on a bacteriophage and is found in >60% of clinical isolates. CHIPS reduces the neutrophil recruitment toward C5a in a mouse peritonitis model, even though its activity is much more potent on human than on mouse cells. These findings suggest a new immune escape mechanism of S. aureus and put forward CHIPS as a potential new antiinflammatory therapeutic compound. |
format | Text |
id | pubmed-2213298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22132982008-03-11 Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent de Haas, Carla J.C. Veldkamp, Karin Ellen Peschel, Andreas Weerkamp, Floor Van Wamel, Willem J.B. Heezius, Erik C.J.M. Poppelier, Miriam J.J.G. Van Kessel, Kok P.M. van Strijp, Jos A.G. J Exp Med Article Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated peptides), complement activation (C5a), and subsequently through activation of leukocytes (e.g., leukotriene B4, platelet-activating factor, and interleukin 8). Here we describe a new protein secreted by Staphylococcus aureus that specifically impairs the response of neutrophils and monocytes to formylated peptides and C5a. This chemotaxis inhibitory protein of S. aureus (CHIPS) is a 14.1-kD protein encoded on a bacteriophage and is found in >60% of clinical isolates. CHIPS reduces the neutrophil recruitment toward C5a in a mouse peritonitis model, even though its activity is much more potent on human than on mouse cells. These findings suggest a new immune escape mechanism of S. aureus and put forward CHIPS as a potential new antiinflammatory therapeutic compound. The Rockefeller University Press 2004-03-01 /pmc/articles/PMC2213298/ /pubmed/14993252 http://dx.doi.org/10.1084/jem.20031636 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article de Haas, Carla J.C. Veldkamp, Karin Ellen Peschel, Andreas Weerkamp, Floor Van Wamel, Willem J.B. Heezius, Erik C.J.M. Poppelier, Miriam J.J.G. Van Kessel, Kok P.M. van Strijp, Jos A.G. Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title | Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title_full | Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title_fullStr | Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title_full_unstemmed | Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title_short | Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent |
title_sort | chemotaxis inhibitory protein of staphylococcus aureus, a bacterial antiinflammatory agent |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213298/ https://www.ncbi.nlm.nih.gov/pubmed/14993252 http://dx.doi.org/10.1084/jem.20031636 |
work_keys_str_mv | AT dehaascarlajc chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT veldkampkarinellen chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT peschelandreas chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT weerkampfloor chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT vanwamelwillemjb chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT heeziuserikcjm chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT poppeliermiriamjjg chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT vankesselkokpm chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent AT vanstrijpjosag chemotaxisinhibitoryproteinofstaphylococcusaureusabacterialantiinflammatoryagent |