Cargando…

Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation

In midgestation mouse embryos, the aorta-gonad-mesonephros (AGM) region generates hematopoietic stem cells and definitive hematopoiesis is regulated by cell–cell interaction and signaling molecules. We showed that a Ras/mitogen-activated protein (MAP) kinase signaling-specific inhibitor and a domina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nobuhisa, Ikuo, Kato, Reiko, Inoue, Hirofumi, Takizawa, Makiko, Okita, Keisuke, Yoshimura, Akihiko, Taga, Tetsuya
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213301/ https://www.ncbi.nlm.nih.gov/pubmed/14981116 http://dx.doi.org/10.1084/jem.20030830

Ejemplares similares

Kit ligand has a critical role in mouse yolk sac and aorta–gonad–mesonephros hematopoiesis
por: Azzoni, Emanuele, et al.
Publicado: (2018)

Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta‐Gonad‐Mesonephros Region
por: Wang, Haizhen, et al.
Publicado: (2023)

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival
por: Lv, Junhua, et al.
Publicado: (2017)

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region
por: Ivanovs, Andrejs, et al.
Publicado: (2011)

Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro
por: Marshall, Caroline J, et al.
Publicado: (2007)

Morphology and immunolocalization of intertubular steroidogenic cell in mesonephros of Podocnemis expansa during gonadal differentiation
por: de Macêdo, Luã Barbalho, et al.
Publicado: (2022)

SPRED1 deletion confers resistance to MAPK inhibition in melanoma
por: Ablain, Julien, et al.
Publicado: (2020)

Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis
por: Gomes Fernandes, Maria, et al.
Publicado: (2018)

Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
por: Inoue, Hiromasa, et al.
Publicado: (2005)

SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance
por: YOSHIMURA, Akihiko, et al.
Publicado: (2021)

Endothelial mTOR maintains hematopoiesis during aging
por: Ramalingam, Pradeep, et al.
Publicado: (2020)

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
por: Viny, Aaron D., et al.
Publicado: (2015)

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis
por: Kim, Peter Geon, et al.
Publicado: (2021)

Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice
por: Xu, Yang, et al.
Publicado: (2014)

Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder
por: Oda, Shinsuke, et al.
Publicado: (2021)

Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice
por: Tian, Mingting, et al.
Publicado: (1997)

Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway
por: Anani, Maha, et al.
Publicado: (2020)

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
por: Yan, Wupeng, et al.
Publicado: (2020)

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
por: Choi, Jae-Hoon, et al.
Publicado: (2009)

The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells
por: Moriyama, Maiko, et al.
Publicado: (2005)

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders
por: Borrie, Sarah C., et al.
Publicado: (2021)

The SPRED1 Variants Repository for Legius Syndrome
por: Sumner, Kelli, et al.
Publicado: (2011)

Progress in experimental research on SPRED protein family
por: Gong, Jian, et al.
Publicado: (2020)

A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
por: Takahashi, Sakuma, et al.
Publicado: (2016)

IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
por: Hanada, Toshikatsu, et al.
Publicado: (2006)

The Sprouty/Spred family as tumor suppressors: Coming of age
por: Kawazoe, Tetsuro, et al.
Publicado: (2019)

SPRED proteins and their roles in signal transduction, development, and malignancy
por: Lorenzo, Claire, et al.
Publicado: (2020)

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals
por: Nishizumi, Hirofumi, et al.
Publicado: (1998)

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells
por: Gao, Tong, et al.
Publicado: (2023)

Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice
por: Ohkura, Takahiro, et al.
Publicado: (2019)

Inflammatory Cytokine Profiles During Exercise in Obese, Diabetic, and Healthy Children
por: Galassetti, Pietro R., et al.
Publicado: (2011)

Complementary and Alternative Medicine in Children with Type 1 Diabetes Mellitus
por: Haliloglu, Belma, et al.
Publicado: (2011)

3M Syndrome: A Report of Four Cases in Two Families
por: Güven, Ayla, et al.
Publicado: (2011)

Modeling and live imaging of mechanical instabilities in the zebrafish aorta during hematopoiesis
por: Chalin, Dmitrii, et al.
Publicado: (2021)

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
por: Takizawa, Makiko, et al.
Publicado: (2008)

Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance
por: Itakura, Junya, et al.
Publicado: (2017)

Legius Syndrome: two novel mutations in the SPRED1 gene
por: Bianchi, Marika, et al.
Publicado: (2015)

STUDIES CONCERNING THE SITE OF RENIN FORMATION IN THE KIDNEY : III. THE APPARENT SITE OF RENIN FORMATION IN THE TUBULES OF THE MESONEPHROS AND METANEPHROS OF THE HOG FETUS
por: Kaplan, A., et al.
Publicado: (1942)

Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin
por: Kawara, Akina, et al.
Publicado: (2020)

Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer
por: Kachroo, N, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_93gqkbi19dfbov2sbgq1dpgd6t