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FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis
The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which include fatal septic shock. Mice deficient in FcγRIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Therefore, we ex...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213308/ https://www.ncbi.nlm.nih.gov/pubmed/14981111 http://dx.doi.org/10.1084/jem.20032197 |
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author | Clatworthy, Menna R. Smith, Kenneth G.C. |
author_facet | Clatworthy, Menna R. Smith, Kenneth G.C. |
author_sort | Clatworthy, Menna R. |
collection | PubMed |
description | The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which include fatal septic shock. Mice deficient in FcγRIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Therefore, we examined whether FcγRIIb controls the response to Streptococcus pneumoniae. Macrophages from FcγRIIb-deficient mice showed increased antibody-dependent phagocytosis of pneumococci in vitro, and consistent with this infected FcγRIIb-deficient mice demonstrated increased bacterial clearance and survival. In contrast, previously immunized FcγRIIb-deficient mice challenged with large inocula showed reduced survival. This correlated with increased production of the sepsis-associated cytokines tumor necrosis factor α and interleukin 6. We propose that FcγRIIb controls the balance between efficient pathogen clearance and the cytokine-mediated consequences of sepsis, with potential therapeutic implications. |
format | Text |
id | pubmed-2213308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22133082008-03-11 FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis Clatworthy, Menna R. Smith, Kenneth G.C. J Exp Med Brief Definitive Report The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which include fatal septic shock. Mice deficient in FcγRIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Therefore, we examined whether FcγRIIb controls the response to Streptococcus pneumoniae. Macrophages from FcγRIIb-deficient mice showed increased antibody-dependent phagocytosis of pneumococci in vitro, and consistent with this infected FcγRIIb-deficient mice demonstrated increased bacterial clearance and survival. In contrast, previously immunized FcγRIIb-deficient mice challenged with large inocula showed reduced survival. This correlated with increased production of the sepsis-associated cytokines tumor necrosis factor α and interleukin 6. We propose that FcγRIIb controls the balance between efficient pathogen clearance and the cytokine-mediated consequences of sepsis, with potential therapeutic implications. The Rockefeller University Press 2004-03-01 /pmc/articles/PMC2213308/ /pubmed/14981111 http://dx.doi.org/10.1084/jem.20032197 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Clatworthy, Menna R. Smith, Kenneth G.C. FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title | FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title_full | FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title_fullStr | FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title_full_unstemmed | FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title_short | FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis |
title_sort | fcγriib balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213308/ https://www.ncbi.nlm.nih.gov/pubmed/14981111 http://dx.doi.org/10.1084/jem.20032197 |
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