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A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination

Somatic hypermutation is initiated by activation-induced cytidine deaminase (AID), and occurs in several kilobases of DNA around rearranged immunoglobulin variable (V) genes and switch (S) sites before constant genes. AID deaminates cytosine to uracil, which can produce mutations of C:G nucleotide p...

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Detalles Bibliográficos
Autores principales:	Martomo, Stella A., Yang, William W., Gearhart, Patricia J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213309/ https://www.ncbi.nlm.nih.gov/pubmed/15238605 http://dx.doi.org/10.1084/jem.20040691

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