Natural HLA Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion

HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively ac...

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Detalles Bibliográficos
Autores principales: Zernich, Danielle, Purcell, Anthony W., Macdonald, Whitney A., Kjer-Nielsen, Lars, Ely, Lauren K., Laham, Nihay, Crockford, Tanya, Mifsud, Nicole A., Bharadwaj, Mandvi, Chang, Linus, Tait, Brian D., Holdsworth, Rhonda, Brooks, Andrew G., Bottomley, Stephen P., Beddoe, Travis, Peh, Chen Au, Rossjohn, Jamie, McCluskey, James
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213310/
https://www.ncbi.nlm.nih.gov/pubmed/15226359
http://dx.doi.org/10.1084/jem.20031680

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