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Cell biology of stem cells: an enigma of asymmetry and self-renewal
Stem cells present a vast, new terrain of cell biology. A central question in stem cell research is how stem cells achieve asymmetric divisions to replicate themselves while producing differentiated daughter cells. This hallmark of stem cells is manifested either strictly during each mitosis or loos...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213586/ https://www.ncbi.nlm.nih.gov/pubmed/18227277 http://dx.doi.org/10.1083/jcb.200712159 |
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author | Lin, Haifan |
author_facet | Lin, Haifan |
author_sort | Lin, Haifan |
collection | PubMed |
description | Stem cells present a vast, new terrain of cell biology. A central question in stem cell research is how stem cells achieve asymmetric divisions to replicate themselves while producing differentiated daughter cells. This hallmark of stem cells is manifested either strictly during each mitosis or loosely among several divisions. Current research has revealed the crucial roles of niche signaling, intrinsic cell polarity, subcellular localization mechanism, asymmetric centrosomes and spindles, as well as cell cycle regulators in establishing self-renewing asymmetry during stem cell division. Much of this progress has benefited from studies in model stem cell systems such as Drosophila melanogaster neuroblasts and germline stem cells and mammalian skin stem cells. Further investigations of these questions in diverse types of stem cells will significantly advance our knowledge of cell biology and allow us to effectively harness stem cells for therapeutic applications. |
format | Text |
id | pubmed-2213586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22135862008-07-28 Cell biology of stem cells: an enigma of asymmetry and self-renewal Lin, Haifan J Cell Biol Reviews Stem cells present a vast, new terrain of cell biology. A central question in stem cell research is how stem cells achieve asymmetric divisions to replicate themselves while producing differentiated daughter cells. This hallmark of stem cells is manifested either strictly during each mitosis or loosely among several divisions. Current research has revealed the crucial roles of niche signaling, intrinsic cell polarity, subcellular localization mechanism, asymmetric centrosomes and spindles, as well as cell cycle regulators in establishing self-renewing asymmetry during stem cell division. Much of this progress has benefited from studies in model stem cell systems such as Drosophila melanogaster neuroblasts and germline stem cells and mammalian skin stem cells. Further investigations of these questions in diverse types of stem cells will significantly advance our knowledge of cell biology and allow us to effectively harness stem cells for therapeutic applications. The Rockefeller University Press 2008-01-28 /pmc/articles/PMC2213586/ /pubmed/18227277 http://dx.doi.org/10.1083/jcb.200712159 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Lin, Haifan Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title | Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title_full | Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title_fullStr | Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title_full_unstemmed | Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title_short | Cell biology of stem cells: an enigma of asymmetry and self-renewal |
title_sort | cell biology of stem cells: an enigma of asymmetry and self-renewal |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213586/ https://www.ncbi.nlm.nih.gov/pubmed/18227277 http://dx.doi.org/10.1083/jcb.200712159 |
work_keys_str_mv | AT linhaifan cellbiologyofstemcellsanenigmaofasymmetryandselfrenewal |