PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

Integrin binding to matrix proteins such as fibronectin (FN) leads to formation of focal adhesion (FA) cellular contact sites that regulate migration. RhoA GTPases facilitate FA formation, yet FA-associated RhoA-specific guanine nucleotide exchange factors (GEFs) remain unknown. Here, we show that p...

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Detalles Bibliográficos
Autores principales: Lim, Yangmi, Lim, Ssang-Taek, Tomar, Alok, Gardel, Margaret, Bernard-Trifilo, Joie A., Chen, Xiao Lei, Uryu, Sean A., Canete-Soler, Rafaela, Zhai, Jinbin, Lin, Hong, Schlaepfer, William W., Nalbant, Perihan, Bokoch, Gary, Ilic, Dusko, Waterman-Storer, Clare, Schlaepfer, David D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213606/
https://www.ncbi.nlm.nih.gov/pubmed/18195107
http://dx.doi.org/10.1083/jcb.200708194

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