KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND

A study of the kinetics of the transformation of swine pepsinogen into pepsin under a variety of conditions has been made. The results show that the transformation as a whole is essentially autocatalytic in nature under all conditions. Evidence is presented to show the existence of a compound interm...

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Detalles Bibliográficos
Autor principal: Herriott, Roger M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1938
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213730/
https://www.ncbi.nlm.nih.gov/pubmed/19873092
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author Herriott, Roger M.
author_facet Herriott, Roger M.
author_sort Herriott, Roger M.
collection PubMed
description A study of the kinetics of the transformation of swine pepsinogen into pepsin under a variety of conditions has been made. The results show that the transformation as a whole is essentially autocatalytic in nature under all conditions. Evidence is presented to show the existence of a compound intermediate between pepsinogen and pepsin. This compound was found to be a reversibly dissociable complex of pepsin and a low molecular weight inhibitor. Some of the general properties of the intermediate compound and of the inhibitor have been examined.
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spelling pubmed-22137302008-04-23 KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND Herriott, Roger M. J Gen Physiol Article A study of the kinetics of the transformation of swine pepsinogen into pepsin under a variety of conditions has been made. The results show that the transformation as a whole is essentially autocatalytic in nature under all conditions. Evidence is presented to show the existence of a compound intermediate between pepsinogen and pepsin. This compound was found to be a reversibly dissociable complex of pepsin and a low molecular weight inhibitor. Some of the general properties of the intermediate compound and of the inhibitor have been examined. The Rockefeller University Press 1938-09-20 /pmc/articles/PMC2213730/ /pubmed/19873092 Text en Copyright © Copyright, 1938, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Herriott, Roger M.
KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title_full KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title_fullStr KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title_full_unstemmed KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title_short KINETICS OF THE FORMATION OF PEPSIN FROM SWINE PEPSINOGEN AND IDENTIFICATION OF AN INTERMEDIATE COMPOUND
title_sort kinetics of the formation of pepsin from swine pepsinogen and identification of an intermediate compound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213730/
https://www.ncbi.nlm.nih.gov/pubmed/19873092
work_keys_str_mv AT herriottrogerm kineticsoftheformationofpepsinfromswinepepsinogenandidentificationofanintermediatecompound

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