Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride

The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chlori...

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Detalles Bibliográficos
Autores principales: Armstrong, Clay M., Binstock, Leonard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213780/
https://www.ncbi.nlm.nih.gov/pubmed/14324992
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author Armstrong, Clay M.
Binstock, Leonard
author_facet Armstrong, Clay M.
Binstock, Leonard
author_sort Armstrong, Clay M.
collection PubMed
description The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. This interference with the flow of outward potassium ion current underlies the prolongation of the action potential seen in tetraethylammonium-injected fibers.
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spelling pubmed-22137802008-04-23 Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride Armstrong, Clay M. Binstock, Leonard J Gen Physiol Article The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. This interference with the flow of outward potassium ion current underlies the prolongation of the action potential seen in tetraethylammonium-injected fibers. The Rockefeller University Press 1965-05-01 /pmc/articles/PMC2213780/ /pubmed/14324992 Text en Copyright © 1965 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Armstrong, Clay M.
Binstock, Leonard
Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title_full Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title_fullStr Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title_full_unstemmed Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title_short Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
title_sort anomalous rectification in the squid giant axon injected with tetraethylammonium chloride
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213780/
https://www.ncbi.nlm.nih.gov/pubmed/14324992
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AT binstockleonard anomalousrectificationinthesquidgiantaxoninjectedwithtetraethylammoniumchloride

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