Inhibitory Phosphorylation of Separase Is Essential for Genome Stability and Viability of Murine Embryonic Germ Cells

Activity of separase, a cysteine protease that cleaves sister chromatid cohesin at the onset of anaphase, is tightly regulated to ensure faithful chromosome segregation and genome stability. Two mechanisms negatively regulate separase: inhibition by securin and phosphorylation on serine 1121. To gau...

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Detalles Bibliográficos
Autores principales: Huang, Xingxu, Andreu-Vieyra, Claudia V, York, J. Philippe, Hatcher, Rashieda, Lu, Tao, Matzuk, Martin M, Zhang, Pumin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214812/
https://www.ncbi.nlm.nih.gov/pubmed/18232736
http://dx.doi.org/10.1371/journal.pbio.0060015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214812/
https://www.ncbi.nlm.nih.gov/pubmed/18232736
http://dx.doi.org/10.1371/journal.pbio.0060015

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