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The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly

Seven D-amino acids, including D-valine, D-phenylalanine, D-leucine, D- isoleucine, D-tryptophan, D-methionine, and D-alpha-aminobutyric acid, are markedly less stimulative than the corresponding L-isomers that can stimulate the labellar sugar receptor of the fleshfly. A distinct effect of len;th of...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215100/
https://www.ncbi.nlm.nih.gov/pubmed/23407
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collection PubMed
description Seven D-amino acids, including D-valine, D-phenylalanine, D-leucine, D- isoleucine, D-tryptophan, D-methionine, and D-alpha-aminobutyric acid, are markedly less stimulative than the corresponding L-isomers that can stimulate the labellar sugar receptor of the fleshfly. A distinct effect of len;th of the amino acid side chain is clearly observed. Esterification and amidation of the alpha-carboxyl group, as well as substitution by hydroxyl and methyl groups, result in extremely decreased responses. Amino acids whose amino groups are located at a position other than the alpha are almost ineffective. With all these rigid stereospecificities of the sugar receptor for amino acids, certain replacement of the alpha-amino group with the hydroxyl or carbonyl group shows a slight increase of the response at neutral pH. Furthermore, certain fatty acids can stimulate the sugar receptor once the solutions are buffered at neutral pH. This observation was further supported by the presence of a remarkable similarity of stimulating effectiveness between amino acids that can stimulate the sugar receptor and those fatty acids. The similarity was shown by testing the response concentration relationships, the stimulating effect of fatty acid derivatives, the effect of treatment with p-chloromercuribenzoate, the behavioral response, and so on.
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spelling pubmed-22151002008-04-23 The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly J Gen Physiol Articles Seven D-amino acids, including D-valine, D-phenylalanine, D-leucine, D- isoleucine, D-tryptophan, D-methionine, and D-alpha-aminobutyric acid, are markedly less stimulative than the corresponding L-isomers that can stimulate the labellar sugar receptor of the fleshfly. A distinct effect of len;th of the amino acid side chain is clearly observed. Esterification and amidation of the alpha-carboxyl group, as well as substitution by hydroxyl and methyl groups, result in extremely decreased responses. Amino acids whose amino groups are located at a position other than the alpha are almost ineffective. With all these rigid stereospecificities of the sugar receptor for amino acids, certain replacement of the alpha-amino group with the hydroxyl or carbonyl group shows a slight increase of the response at neutral pH. Furthermore, certain fatty acids can stimulate the sugar receptor once the solutions are buffered at neutral pH. This observation was further supported by the presence of a remarkable similarity of stimulating effectiveness between amino acids that can stimulate the sugar receptor and those fatty acids. The similarity was shown by testing the response concentration relationships, the stimulating effect of fatty acid derivatives, the effect of treatment with p-chloromercuribenzoate, the behavioral response, and so on. The Rockefeller University Press 1978-01-01 /pmc/articles/PMC2215100/ /pubmed/23407 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title_full The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title_fullStr The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title_full_unstemmed The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title_short The stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
title_sort stimulating effect of fatty acids and amino acid derivatives on the labellar sugar receptor of the fleshfly
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215100/
https://www.ncbi.nlm.nih.gov/pubmed/23407