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Synaptic facilitation in Aplysia explored by random presynaptic stimulation

The identified interneuron L10 in the abdominal ganglion of Aplysia was stimulated to fire action potentials in a random sequence while the early inhibitory potential of its follower cell L2 was recorded. Application of Wiener nonlinear analysis to these data yielded a predictive model of the facili...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215203/
https://www.ncbi.nlm.nih.gov/pubmed/225406
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collection PubMed
description The identified interneuron L10 in the abdominal ganglion of Aplysia was stimulated to fire action potentials in a random sequence while the early inhibitory potential of its follower cell L2 was recorded. Application of Wiener nonlinear analysis to these data yielded a predictive model of the facilitating postsynaptic potential. The model shows that facilitation changes both the time-course and the magnitude of the early synaptic potential. The facilitated response has a longer duration than the unfacilitated response. Its magnitude is exponentially decreasing with increasing interstimulus interval between test and conditioning stimuli. Facilitation is abolished at short interstimulus intervals. The hypothesis that the magnitude only of transmitter release is increased cannot explain these results. The observed facilitation may be due to characteristics of pre- and postsynaptic morphology.
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spelling pubmed-22152032008-04-23 Synaptic facilitation in Aplysia explored by random presynaptic stimulation J Gen Physiol Articles The identified interneuron L10 in the abdominal ganglion of Aplysia was stimulated to fire action potentials in a random sequence while the early inhibitory potential of its follower cell L2 was recorded. Application of Wiener nonlinear analysis to these data yielded a predictive model of the facilitating postsynaptic potential. The model shows that facilitation changes both the time-course and the magnitude of the early synaptic potential. The facilitated response has a longer duration than the unfacilitated response. Its magnitude is exponentially decreasing with increasing interstimulus interval between test and conditioning stimuli. Facilitation is abolished at short interstimulus intervals. The hypothesis that the magnitude only of transmitter release is increased cannot explain these results. The observed facilitation may be due to characteristics of pre- and postsynaptic morphology. The Rockefeller University Press 1979-06-01 /pmc/articles/PMC2215203/ /pubmed/225406 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title_full Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title_fullStr Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title_full_unstemmed Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title_short Synaptic facilitation in Aplysia explored by random presynaptic stimulation
title_sort synaptic facilitation in aplysia explored by random presynaptic stimulation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215203/
https://www.ncbi.nlm.nih.gov/pubmed/225406