Nonlinear cable equations for axons. I. Computations and experiments with internal current injection

Steady-state potential and current distributions resulting from internal injection of current in the squid giant axon have been measured experimentally and also computed from nonlinear membrane cable equation models by numerical methods, using the Hodgkin-Huxley equations to give the membrane curren...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215206/
https://www.ncbi.nlm.nih.gov/pubmed/479812
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collection PubMed
description Steady-state potential and current distributions resulting from internal injection of current in the squid giant axon have been measured experimentally and also computed from nonlinear membrane cable equation models by numerical methods, using the Hodgkin-Huxley equations to give the membrane current density. The solutions obtained by this method satisfactorily reproduce experimental measurements of the steady-state distribution of membrane potential. Computations of the input current-voltage characteristic for a nonlinear cable were in excellent agreement with measurements on axons. Our results demonstrate the power of Cole's equation to extract the nonlinear membrane characteristics simply from measurement of the input resistance.
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spelling pubmed-22152062008-04-23 Nonlinear cable equations for axons. I. Computations and experiments with internal current injection J Gen Physiol Articles Steady-state potential and current distributions resulting from internal injection of current in the squid giant axon have been measured experimentally and also computed from nonlinear membrane cable equation models by numerical methods, using the Hodgkin-Huxley equations to give the membrane current density. The solutions obtained by this method satisfactorily reproduce experimental measurements of the steady-state distribution of membrane potential. Computations of the input current-voltage characteristic for a nonlinear cable were in excellent agreement with measurements on axons. Our results demonstrate the power of Cole's equation to extract the nonlinear membrane characteristics simply from measurement of the input resistance. The Rockefeller University Press 1979-06-01 /pmc/articles/PMC2215206/ /pubmed/479812 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title_full Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title_fullStr Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title_full_unstemmed Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title_short Nonlinear cable equations for axons. I. Computations and experiments with internal current injection
title_sort nonlinear cable equations for axons. i. computations and experiments with internal current injection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215206/
https://www.ncbi.nlm.nih.gov/pubmed/479812

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