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A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis

BACKGROUND: Recent discoveries in the field of somitogenesis have confirmed, for the most part, the feasibility of the clock and wavefront model. There are good candidates for both the clock (various genes expressed cyclically in the tail bud of vertebrate embryos have been discovered) and the wavef...

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Detalles Bibliográficos
Autores principales: Santillán, Moisés, Mackey, Michael C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2216431/
https://www.ncbi.nlm.nih.gov/pubmed/18253505
http://dx.doi.org/10.1371/journal.pone.0001561
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author Santillán, Moisés
Mackey, Michael C.
author_facet Santillán, Moisés
Mackey, Michael C.
author_sort Santillán, Moisés
collection PubMed
description BACKGROUND: Recent discoveries in the field of somitogenesis have confirmed, for the most part, the feasibility of the clock and wavefront model. There are good candidates for both the clock (various genes expressed cyclically in the tail bud of vertebrate embryos have been discovered) and the wavefront (there are at least three different substances, whose expression levels vary along the presomitic mesoderm [PSM], that have important effects on the formation of somites). Nevertheless, the mechanisms through which the wavefront interacts with the clock to arrest the oscillations and induce somite formation have not yet been fully elucidated. PRINCIPAL FINDINGS: In this work, we propose a gene regulatory network which is consistent with all known experimental facts in embryonic mice, and whose dynamic behaviour provides a potential explanation for the periodic aggregation of PSM cells into blocks: the first step leading to the formation of somites. SIGNIFICANCE: To our knowledge, this is the first proposed mechanism that fully explains how a block of PSM cells can stop oscillating simultaneously, and how this process is repeated periodically, via the interaction of the segmentation clock and the determination front.
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spelling pubmed-22164312008-02-06 A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis Santillán, Moisés Mackey, Michael C. PLoS One Research Article BACKGROUND: Recent discoveries in the field of somitogenesis have confirmed, for the most part, the feasibility of the clock and wavefront model. There are good candidates for both the clock (various genes expressed cyclically in the tail bud of vertebrate embryos have been discovered) and the wavefront (there are at least three different substances, whose expression levels vary along the presomitic mesoderm [PSM], that have important effects on the formation of somites). Nevertheless, the mechanisms through which the wavefront interacts with the clock to arrest the oscillations and induce somite formation have not yet been fully elucidated. PRINCIPAL FINDINGS: In this work, we propose a gene regulatory network which is consistent with all known experimental facts in embryonic mice, and whose dynamic behaviour provides a potential explanation for the periodic aggregation of PSM cells into blocks: the first step leading to the formation of somites. SIGNIFICANCE: To our knowledge, this is the first proposed mechanism that fully explains how a block of PSM cells can stop oscillating simultaneously, and how this process is repeated periodically, via the interaction of the segmentation clock and the determination front. Public Library of Science 2008-02-06 /pmc/articles/PMC2216431/ /pubmed/18253505 http://dx.doi.org/10.1371/journal.pone.0001561 Text en Santillan, Mackey. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Santillán, Moisés
Mackey, Michael C.
A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title_full A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title_fullStr A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title_full_unstemmed A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title_short A Proposed Mechanism for the Interaction of the Segmentation Clock and the Determination Front in Somitogenesis
title_sort proposed mechanism for the interaction of the segmentation clock and the determination front in somitogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2216431/
https://www.ncbi.nlm.nih.gov/pubmed/18253505
http://dx.doi.org/10.1371/journal.pone.0001561
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