Mutation in the M1 Domain of the Acetylcholine Receptor α Subunit Decreases the Rate of Agonist Dissociation

We describe the kinetic consequences of the mutation N217K in the M1 domain of the acetylcholine receptor (AChR) α subunit that causes a slow channel congenital myasthenic syndrome (SCCMS). We previously showed that receptors containing αN217K expressed in 293 HEK cells open in prolonged activation...

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Detalles Bibliográficos
Autores principales: Wang, Hai-Long, Auerbach, Anthony, Bren, Nina, Ohno, Kinji, Engel, Andrew G., Sine, Steven M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217038/
https://www.ncbi.nlm.nih.gov/pubmed/9222901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217038/
https://www.ncbi.nlm.nih.gov/pubmed/9222901

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