Glutamine Substitution at Alanine(1649) in the S4–S5 Cytoplasmic Loop of Domain 4 Removes the Voltage Sensitivity of Fast Inactivation in the Human Heart Sodium Channel

Normal activation–inactivation coupling in sodium channels insures that inactivation is slow at small but rapid at large depolarizations. M1651Q/M1652Q substitutions in the cytoplasmic loop connecting the fourth and fifth transmembrane segments of Domain 4 (S4–S5/D4) of the human heart sodium channe...

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Detalles Bibliográficos
Autores principales: Tang, Lihui, Chehab, Nabil, Wieland, Steven J., Kallen, Roland G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217139/
https://www.ncbi.nlm.nih.gov/pubmed/9565402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217139/
https://www.ncbi.nlm.nih.gov/pubmed/9565402

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