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Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate

Deactivation of voltage-gated potassium (K(+)) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to trapping of the compound within the inner vestibule by closure of the activation gate. Unbinding and exit from the channel vestibule of a posit...

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Detalles Bibliográficos
Autores principales:	Mitcheson, John S., Chen, Jun, Sanguinetti, Michael C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217217/ https://www.ncbi.nlm.nih.gov/pubmed/10694252

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