Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels: Evidence for an Intracellular Activation Gate

Hyperpolarization-activated cation currents (I(h)) are key determinants of repetitive electrical activity in heart and nerve cells. The bradycardic agent ZD7288 is a selective blocker of these currents. We studied the mechanism for ZD7288 blockade of cloned I(h) channels in excised inside-out patche...

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Detalles Bibliográficos
Autores principales: Shin, Ki Soon, Rothberg, Brad S., Yellen, Gary
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217248/
https://www.ncbi.nlm.nih.gov/pubmed/11158163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217248/
https://www.ncbi.nlm.nih.gov/pubmed/11158163

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