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On the Mechanism of MgATP-dependent Gating of CFTR Cl(−) Channels
CFTR, the product of the gene mutated in cystic fibrosis, is an ATPase that functions as a Cl(−) channel in which bursts of openings separate relatively long interburst closed times (τib). Channel gating is controlled by phosphorylation and MgATP, but the underlying molecular mechanisms remain contr...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217317/ https://www.ncbi.nlm.nih.gov/pubmed/12508051 http://dx.doi.org/10.1085/jgp.20028673 |