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Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K(+) Current Inhibition
Extracellular acidification is known to decrease the conductance of many voltage-gated potassium channels. In the present study, we investigated the mechanism of H(+) (o)-induced current inhibition by taking advantage of Na(+) permeation through inactivated channels. In hKv1.5, H(+) (o) inhibited op...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217332/ https://www.ncbi.nlm.nih.gov/pubmed/12601085 http://dx.doi.org/10.1085/jgp.20028760 |