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Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization–activated HCN Channels

The positively charged S4 transmembrane segment of voltage-gated channels is thought to function as the voltage sensor by moving charge through the membrane electric field in response to depolarization. Here we studied S4 movements in the mammalian HCN pacemaker channels. Unlike most voltage-gated c...

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Detalles Bibliográficos
Autores principales:	Bell, Damian C., Yao, Huan, Saenger, Renee C., Riley, John H., Siegelbaum, Steven A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217414/ https://www.ncbi.nlm.nih.gov/pubmed/14676285 http://dx.doi.org/10.1085/jgp.200308918

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