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Preferential Phosphorylation of R-domain Serine 768 Dampens Activation of CFTR Channels by PKA

CFTR (cystic fibrosis transmembrane conductance regulator), the protein whose dysfunction causes cystic fibrosis, is a chloride ion channel whose gating is controlled by interactions of MgATP with CFTR's two cytoplasmic nucleotide binding domains, but only after several serines in CFTR's r...

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Detalles Bibliográficos
Autores principales:	Csanády, László, Seto-Young, Donna, Chan, Kim W., Cenciarelli, Cristina, Angel, Benjamin B., Qin, Jun, McLachlin, Derek T., Krutchinsky, Andrew N., Chait, Brian T., Nairn, Angus C., Gadsby, David C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217491/ https://www.ncbi.nlm.nih.gov/pubmed/15657296 http://dx.doi.org/10.1085/jgp.200409076

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