HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo

Classically, HLA-DR expressed on antigen presenting cells (APC) initiates lymphocyte activation via presentation of peptides to TCR bearing CD4+ T-Cells. Here we demonstrate that HLA-DR alpha 2 domain (sHLA-DRα2) also induces negative signals by engaging TIRC7 on lymphocytes. This interaction inhibi...

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Detalles Bibliográficos
Autores principales: Bulwin, Grit-Carsta, Wälter, Stephanie, Schlawinsky, Mirko, Heinemann, Thomas, Schulze, Anke, Höhne, Wolfgang, Krause, Gerd, Kalka-Moll, Wiltrud, Fraser, Patricia, Volk, Hans-Dieter, Löhler, Jürgen, Milford, Edgar L., Utku, Nalân
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217592/
https://www.ncbi.nlm.nih.gov/pubmed/18270567
http://dx.doi.org/10.1371/journal.pone.0001576

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