New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)

A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard transloca...

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Detalles Bibliográficos
Autores principales: El Andaloussi, Abdeljabar, Bilhou-Nabera, Chrystele
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219519/
https://www.ncbi.nlm.nih.gov/pubmed/18273416
http://dx.doi.org/10.1155/2007/92385
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author El Andaloussi, Abdeljabar
Bilhou-Nabera, Chrystele
author_facet El Andaloussi, Abdeljabar
Bilhou-Nabera, Chrystele
author_sort El Andaloussi, Abdeljabar
collection PubMed
description A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translocations have the same prognosis. The patient was treated with standard initial therapy based on hydroxyurea before he died due to heart failure four months later. Our finding indicates the importance of combined cytogenetic analysis for diagnosis and guidance of treatment in clinical diagnosis of CML.
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spelling pubmed-22195192008-02-13 New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11) El Andaloussi, Abdeljabar Bilhou-Nabera, Chrystele J Biomed Biotechnol Case Report A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translocations have the same prognosis. The patient was treated with standard initial therapy based on hydroxyurea before he died due to heart failure four months later. Our finding indicates the importance of combined cytogenetic analysis for diagnosis and guidance of treatment in clinical diagnosis of CML. Hindawi Publishing Corporation 2007 2007-12-26 /pmc/articles/PMC2219519/ /pubmed/18273416 http://dx.doi.org/10.1155/2007/92385 Text en Copyright © 2007 A. El Andaloussi and C. Bilhou-Nabera. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
El Andaloussi, Abdeljabar
Bilhou-Nabera, Chrystele
New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_full New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_fullStr New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_full_unstemmed New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_short New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_sort new complex chromosomal translocation in chronic myeloid leukaemia: t(9;18;22)(q34;p11;q11)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219519/
https://www.ncbi.nlm.nih.gov/pubmed/18273416
http://dx.doi.org/10.1155/2007/92385
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AT bilhounaberachrystele newcomplexchromosomaltranslocationinchronicmyeloidleukaemiat91822q34p11q11

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