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Trafficking of central opioid receptors and descending pain inhibition
The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes involving its C-tail motifs, intracellular sorting proteins, and several intracellular sign...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219988/ https://www.ncbi.nlm.nih.gov/pubmed/18053223 http://dx.doi.org/10.1186/1744-8069-3-37 |
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author | Bie, Bihua Pan, Zhizhong Z |
author_facet | Bie, Bihua Pan, Zhizhong Z |
author_sort | Bie, Bihua |
collection | PubMed |
description | The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes involving its C-tail motifs, intracellular sorting proteins, and several intracellular signaling pathways. In the quiescent state, DOR is generally located in the intracellular compartments in central neurons. However, chronic stimulation, such as chronic pain and sustained opioid exposure, may induce membrane trafficking of DOR and its translocation to surface membrane. The emerged functional DOR on cell membrane is actively involved in pain modulation and opioid analgesia. This article reviews current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances. |
format | Text |
id | pubmed-2219988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22199882008-01-31 Trafficking of central opioid receptors and descending pain inhibition Bie, Bihua Pan, Zhizhong Z Mol Pain Review The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes involving its C-tail motifs, intracellular sorting proteins, and several intracellular signaling pathways. In the quiescent state, DOR is generally located in the intracellular compartments in central neurons. However, chronic stimulation, such as chronic pain and sustained opioid exposure, may induce membrane trafficking of DOR and its translocation to surface membrane. The emerged functional DOR on cell membrane is actively involved in pain modulation and opioid analgesia. This article reviews current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances. BioMed Central 2007-12-04 /pmc/articles/PMC2219988/ /pubmed/18053223 http://dx.doi.org/10.1186/1744-8069-3-37 Text en Copyright © 2007 Bie and Pan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bie, Bihua Pan, Zhizhong Z Trafficking of central opioid receptors and descending pain inhibition |
title | Trafficking of central opioid receptors and descending pain inhibition |
title_full | Trafficking of central opioid receptors and descending pain inhibition |
title_fullStr | Trafficking of central opioid receptors and descending pain inhibition |
title_full_unstemmed | Trafficking of central opioid receptors and descending pain inhibition |
title_short | Trafficking of central opioid receptors and descending pain inhibition |
title_sort | trafficking of central opioid receptors and descending pain inhibition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219988/ https://www.ncbi.nlm.nih.gov/pubmed/18053223 http://dx.doi.org/10.1186/1744-8069-3-37 |
work_keys_str_mv | AT biebihua traffickingofcentralopioidreceptorsanddescendingpaininhibition AT panzhizhongz traffickingofcentralopioidreceptorsanddescendingpaininhibition |