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Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phag...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220046/ https://www.ncbi.nlm.nih.gov/pubmed/18253476 http://dx.doi.org/10.1155/2007/52546 |
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author | Aronoff, David M. Serezani, Carlos H. Carstens, Jennifer K. Marshall, Teresa Gangireddy, Srinivasa R. Peters-Golden, Marc Reddy, Raju C. |
author_facet | Aronoff, David M. Serezani, Carlos H. Carstens, Jennifer K. Marshall, Teresa Gangireddy, Srinivasa R. Peters-Golden, Marc Reddy, Raju C. |
author_sort | Aronoff, David M. |
collection | PubMed |
description | Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phagocytosis of lipids, apoptotic neutrophils, and other unopsonized materials. These effects led us to investigate the actions of PPAR- [Formula: see text] agonists on the Fc [Formula: see text] receptor, which mediates phagocytosis of particles opsonized by binding of immunoglobulin G antibodies. We found that troglitazone, rosiglitazone, and 15-deoxy- [Formula: see text]-prostaglandin [Formula: see text] increase the ability of alveolar, but not peritoneal, macrophages to carry out phagocytosis mediated by the Fc [Formula: see text] receptor. Receptor expression was not altered but activation of the downstream signaling proteins Syk, ERK-1, and ERK-2 was observed. Although it was previously known that PPAR- [Formula: see text] ligands stimulate phagocytosis of unopsonized materials, this is the first demonstration that they stimulate phagocytosis of opsonized materials as well. |
format | Text |
id | pubmed-2220046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22200462008-02-05 Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages Aronoff, David M. Serezani, Carlos H. Carstens, Jennifer K. Marshall, Teresa Gangireddy, Srinivasa R. Peters-Golden, Marc Reddy, Raju C. PPAR Res Research Article Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phagocytosis of lipids, apoptotic neutrophils, and other unopsonized materials. These effects led us to investigate the actions of PPAR- [Formula: see text] agonists on the Fc [Formula: see text] receptor, which mediates phagocytosis of particles opsonized by binding of immunoglobulin G antibodies. We found that troglitazone, rosiglitazone, and 15-deoxy- [Formula: see text]-prostaglandin [Formula: see text] increase the ability of alveolar, but not peritoneal, macrophages to carry out phagocytosis mediated by the Fc [Formula: see text] receptor. Receptor expression was not altered but activation of the downstream signaling proteins Syk, ERK-1, and ERK-2 was observed. Although it was previously known that PPAR- [Formula: see text] ligands stimulate phagocytosis of unopsonized materials, this is the first demonstration that they stimulate phagocytosis of opsonized materials as well. Hindawi Publishing Corporation 2007 2007-10-02 /pmc/articles/PMC2220046/ /pubmed/18253476 http://dx.doi.org/10.1155/2007/52546 Text en Copyright © 2007 David M. Aronoff et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Aronoff, David M. Serezani, Carlos H. Carstens, Jennifer K. Marshall, Teresa Gangireddy, Srinivasa R. Peters-Golden, Marc Reddy, Raju C. Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title | Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title_full | Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title_fullStr | Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title_full_unstemmed | Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title_short | Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages |
title_sort | stimulatory effects of peroxisome proliferator-activated receptor- [formula: see text] on fc [formula: see text] receptor-mediated phagocytosis by alveolar macrophages |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220046/ https://www.ncbi.nlm.nih.gov/pubmed/18253476 http://dx.doi.org/10.1155/2007/52546 |
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