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Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages

Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phag...

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Autores principales: Aronoff, David M., Serezani, Carlos H., Carstens, Jennifer K., Marshall, Teresa, Gangireddy, Srinivasa R., Peters-Golden, Marc, Reddy, Raju C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220046/
https://www.ncbi.nlm.nih.gov/pubmed/18253476
http://dx.doi.org/10.1155/2007/52546
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author Aronoff, David M.
Serezani, Carlos H.
Carstens, Jennifer K.
Marshall, Teresa
Gangireddy, Srinivasa R.
Peters-Golden, Marc
Reddy, Raju C.
author_facet Aronoff, David M.
Serezani, Carlos H.
Carstens, Jennifer K.
Marshall, Teresa
Gangireddy, Srinivasa R.
Peters-Golden, Marc
Reddy, Raju C.
author_sort Aronoff, David M.
collection PubMed
description Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phagocytosis of lipids, apoptotic neutrophils, and other unopsonized materials. These effects led us to investigate the actions of PPAR- [Formula: see text] agonists on the Fc [Formula: see text] receptor, which mediates phagocytosis of particles opsonized by binding of immunoglobulin G antibodies. We found that troglitazone, rosiglitazone, and 15-deoxy- [Formula: see text]-prostaglandin [Formula: see text] increase the ability of alveolar, but not peritoneal, macrophages to carry out phagocytosis mediated by the Fc [Formula: see text] receptor. Receptor expression was not altered but activation of the downstream signaling proteins Syk, ERK-1, and ERK-2 was observed. Although it was previously known that PPAR- [Formula: see text] ligands stimulate phagocytosis of unopsonized materials, this is the first demonstration that they stimulate phagocytosis of opsonized materials as well.
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spelling pubmed-22200462008-02-05 Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages Aronoff, David M. Serezani, Carlos H. Carstens, Jennifer K. Marshall, Teresa Gangireddy, Srinivasa R. Peters-Golden, Marc Reddy, Raju C. PPAR Res Research Article Alveolar macrophages abundantly express PPAR- [Formula: see text] , with both natural and synthetic agonists maintaining the cell in a quiescent state hyporesponsive to antigen stimulation. Conversely, agonists upregulate expression and function of the cell-surface receptor CD36, which mediates phagocytosis of lipids, apoptotic neutrophils, and other unopsonized materials. These effects led us to investigate the actions of PPAR- [Formula: see text] agonists on the Fc [Formula: see text] receptor, which mediates phagocytosis of particles opsonized by binding of immunoglobulin G antibodies. We found that troglitazone, rosiglitazone, and 15-deoxy- [Formula: see text]-prostaglandin [Formula: see text] increase the ability of alveolar, but not peritoneal, macrophages to carry out phagocytosis mediated by the Fc [Formula: see text] receptor. Receptor expression was not altered but activation of the downstream signaling proteins Syk, ERK-1, and ERK-2 was observed. Although it was previously known that PPAR- [Formula: see text] ligands stimulate phagocytosis of unopsonized materials, this is the first demonstration that they stimulate phagocytosis of opsonized materials as well. Hindawi Publishing Corporation 2007 2007-10-02 /pmc/articles/PMC2220046/ /pubmed/18253476 http://dx.doi.org/10.1155/2007/52546 Text en Copyright © 2007 David M. Aronoff et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aronoff, David M.
Serezani, Carlos H.
Carstens, Jennifer K.
Marshall, Teresa
Gangireddy, Srinivasa R.
Peters-Golden, Marc
Reddy, Raju C.
Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title_full Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title_fullStr Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title_full_unstemmed Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title_short Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- [Formula: see text] on Fc [Formula: see text] Receptor-Mediated Phagocytosis by Alveolar Macrophages
title_sort stimulatory effects of peroxisome proliferator-activated receptor- [formula: see text] on fc [formula: see text] receptor-mediated phagocytosis by alveolar macrophages
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220046/
https://www.ncbi.nlm.nih.gov/pubmed/18253476
http://dx.doi.org/10.1155/2007/52546
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