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Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV

The molecular mechanisms for plastic deformation of bone tissue are not well understood. We analysed temperature and strain-rate dependence of the tensile deformation behaviour in fibrolamellar bone, using a technique originally developed for studying plastic deformation in metals. We show that, bey...

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Autores principales: Gupta, Himadri S, Fratzl, Peter, Kerschnitzki, Michael, Benecke, Gunthard, Wagermaier, Wolfgang, Kirchner, Helmut O.K
Formato: Texto
Lenguaje:English
Publicado: The Royal Society 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220070/
https://www.ncbi.nlm.nih.gov/pubmed/17251154
http://dx.doi.org/10.1098/rsif.2006.0172
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author Gupta, Himadri S
Fratzl, Peter
Kerschnitzki, Michael
Benecke, Gunthard
Wagermaier, Wolfgang
Kirchner, Helmut O.K
author_facet Gupta, Himadri S
Fratzl, Peter
Kerschnitzki, Michael
Benecke, Gunthard
Wagermaier, Wolfgang
Kirchner, Helmut O.K
author_sort Gupta, Himadri S
collection PubMed
description The molecular mechanisms for plastic deformation of bone tissue are not well understood. We analysed temperature and strain-rate dependence of the tensile deformation behaviour in fibrolamellar bone, using a technique originally developed for studying plastic deformation in metals. We show that, beyond the elastic regime, bone is highly strain-rate sensitive, with an activation volume of ca 0.6 nm(3). We find an activation energy of 1.1 eV associated with the basic step involved in the plastic deformation of bone at the molecular level. This is much higher than the energy of hydrogen bonds, but it is lower than the energy required for breaking covalent bonds inside the collagen fibrils. Based on the magnitude of these quantities, we speculate that disruption of electrostatic bonds between polyelectrolyte molecules in the extrafibrillar matrix of bone, perhaps mediated by polyvalent ions such as calcium, may be the rate-limiting elementary step in bone plasticity.
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spelling pubmed-22200702008-02-20 Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV Gupta, Himadri S Fratzl, Peter Kerschnitzki, Michael Benecke, Gunthard Wagermaier, Wolfgang Kirchner, Helmut O.K J R Soc Interface Research Article The molecular mechanisms for plastic deformation of bone tissue are not well understood. We analysed temperature and strain-rate dependence of the tensile deformation behaviour in fibrolamellar bone, using a technique originally developed for studying plastic deformation in metals. We show that, beyond the elastic regime, bone is highly strain-rate sensitive, with an activation volume of ca 0.6 nm(3). We find an activation energy of 1.1 eV associated with the basic step involved in the plastic deformation of bone at the molecular level. This is much higher than the energy of hydrogen bonds, but it is lower than the energy required for breaking covalent bonds inside the collagen fibrils. Based on the magnitude of these quantities, we speculate that disruption of electrostatic bonds between polyelectrolyte molecules in the extrafibrillar matrix of bone, perhaps mediated by polyvalent ions such as calcium, may be the rate-limiting elementary step in bone plasticity. The Royal Society 2006-11-07 2007-04-22 /pmc/articles/PMC2220070/ /pubmed/17251154 http://dx.doi.org/10.1098/rsif.2006.0172 Text en Copyright © 2006 The Royal Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gupta, Himadri S
Fratzl, Peter
Kerschnitzki, Michael
Benecke, Gunthard
Wagermaier, Wolfgang
Kirchner, Helmut O.K
Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title_full Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title_fullStr Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title_full_unstemmed Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title_short Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
title_sort evidence for an elementary process in bone plasticity with an activation enthalpy of 1 ev
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220070/
https://www.ncbi.nlm.nih.gov/pubmed/17251154
http://dx.doi.org/10.1098/rsif.2006.0172
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