Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)

The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression from an HIV-1 LTR-reporter as well as fr...

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Autores principales: Lee, Jia Hai, Yedavalli, Venkat RK, Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222664/
https://www.ncbi.nlm.nih.gov/pubmed/18078512
http://dx.doi.org/10.1186/1742-4690-4-91
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author Lee, Jia Hai
Yedavalli, Venkat RK
Jeang, Kuan-Teh
author_facet Lee, Jia Hai
Yedavalli, Venkat RK
Jeang, Kuan-Teh
author_sort Lee, Jia Hai
collection PubMed
description The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3. Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP agonists and cGMP antagonists caused respectively increased and decreased virus replication. These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells.
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spelling pubmed-22226642008-02-01 Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β) Lee, Jia Hai Yedavalli, Venkat RK Jeang, Kuan-Teh Retrovirology Short Report The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3. Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP agonists and cGMP antagonists caused respectively increased and decreased virus replication. These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells. BioMed Central 2007-12-13 /pmc/articles/PMC2222664/ /pubmed/18078512 http://dx.doi.org/10.1186/1742-4690-4-91 Text en Copyright © 2007 Lee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Lee, Jia Hai
Yedavalli, Venkat RK
Jeang, Kuan-Teh
Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title_full Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title_fullStr Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title_full_unstemmed Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title_short Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
title_sort activation of hiv-1 expression and replication by cgmp dependent protein kinase type 1-β (pkg1β)
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222664/
https://www.ncbi.nlm.nih.gov/pubmed/18078512
http://dx.doi.org/10.1186/1742-4690-4-91
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AT jeangkuanteh activationofhiv1expressionandreplicationbycgmpdependentproteinkinasetype1bpkg1b

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