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p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

The expression of the p53 and Rb1 proteins was examined in an unselected consecutive series of 250 primary operable colorectal carcinomas with a mean follow-up of 4.3 years (range 43-77 months). The overall cancer-specific mortality was 34.8%, with 87 cancer deaths and 35 deaths as the result of oth...

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Autores principales: Poller, D. N., Baxter, K. J., Shepherd, N. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222690/
https://www.ncbi.nlm.nih.gov/pubmed/9000603
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author Poller, D. N.
Baxter, K. J.
Shepherd, N. A.
author_facet Poller, D. N.
Baxter, K. J.
Shepherd, N. A.
author_sort Poller, D. N.
collection PubMed
description The expression of the p53 and Rb1 proteins was examined in an unselected consecutive series of 250 primary operable colorectal carcinomas with a mean follow-up of 4.3 years (range 43-77 months). The overall cancer-specific mortality was 34.8%, with 87 cancer deaths and 35 deaths as the result of other causes. Expression of p53 protein was identified in 152 of 250 (60.8%) cases, with expression of Rb1 protein in 207 of 250 (82.8%) cases. There was no association of p53 or Rb protein expression with patient age, sex, tumour site, tumour size, tumour type, tumour grade, peritumoral fibrosis, tumour lymphocytic infiltrate, nature of the tumour margin, extramural vascular invasion, number of lymph nodes or high apical lymph node involved or local peritoneal infiltration by tumour, Dukes' stage or Jass group. There was no difference in overall survival or recurrence-free survival for those cases that showed p53 expression or Rb1 protein expression compared with those cases showing absence of p53 or Rb1 protein expression, although patients with tumours showing aberrant (reduced) Rb1 protein expression demonstrated shorter recurrence-free survival and overall survival. The effect of 'aberrant' Rb1 protein expression and shorter recurrence-free and overall survival did not, however, achieve independent statistical significance. The results from this study would suggest that expression of p53 and Rb1 proteins does not appear be useful in determining the prognosis of operable colorectal cancer. IMAGES:
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spelling pubmed-22226902009-09-10 p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? Poller, D. N. Baxter, K. J. Shepherd, N. A. Br J Cancer Research Article The expression of the p53 and Rb1 proteins was examined in an unselected consecutive series of 250 primary operable colorectal carcinomas with a mean follow-up of 4.3 years (range 43-77 months). The overall cancer-specific mortality was 34.8%, with 87 cancer deaths and 35 deaths as the result of other causes. Expression of p53 protein was identified in 152 of 250 (60.8%) cases, with expression of Rb1 protein in 207 of 250 (82.8%) cases. There was no association of p53 or Rb protein expression with patient age, sex, tumour site, tumour size, tumour type, tumour grade, peritumoral fibrosis, tumour lymphocytic infiltrate, nature of the tumour margin, extramural vascular invasion, number of lymph nodes or high apical lymph node involved or local peritoneal infiltration by tumour, Dukes' stage or Jass group. There was no difference in overall survival or recurrence-free survival for those cases that showed p53 expression or Rb1 protein expression compared with those cases showing absence of p53 or Rb1 protein expression, although patients with tumours showing aberrant (reduced) Rb1 protein expression demonstrated shorter recurrence-free survival and overall survival. The effect of 'aberrant' Rb1 protein expression and shorter recurrence-free and overall survival did not, however, achieve independent statistical significance. The results from this study would suggest that expression of p53 and Rb1 proteins does not appear be useful in determining the prognosis of operable colorectal cancer. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2222690/ /pubmed/9000603 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Poller, D. N.
Baxter, K. J.
Shepherd, N. A.
p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title_full p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title_fullStr p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title_full_unstemmed p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title_short p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?
title_sort p53 and rb1 protein expression: are they prognostically useful in colorectal cancer?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222690/
https://www.ncbi.nlm.nih.gov/pubmed/9000603
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