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Ion Channel Selectivity through Stepwise Changes in Binding Affinity
Voltage-gated Ca(2+) channels select Ca(2+) over competing, more abundant ions by means of a high affinity binding site in the pore. The maximum off rate from this site is ∼1,000× slower than observed Ca(2+) current. Various theories that explain how high Ca(2+) current can pass through such a stick...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222772/ https://www.ncbi.nlm.nih.gov/pubmed/9450938 |