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Ion Channel Selectivity through Stepwise Changes in Binding Affinity

Voltage-gated Ca(2+) channels select Ca(2+) over competing, more abundant ions by means of a high affinity binding site in the pore. The maximum off rate from this site is ∼1,000× slower than observed Ca(2+) current. Various theories that explain how high Ca(2+) current can pass through such a stick...

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Detalles Bibliográficos
Autores principales: Dang, Thieu X., McCleskey, Edwin W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222772/
https://www.ncbi.nlm.nih.gov/pubmed/9450938

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