Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.

To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No ge...

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Detalles Bibliográficos
Autores principales: Zelada-Hedman, M., Børresen-Dale, A. L., Claro, A., Chen, J., Skoog, L., Lindblom, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222784/
https://www.ncbi.nlm.nih.gov/pubmed/9099970
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author Zelada-Hedman, M.
Børresen-Dale, A. L.
Claro, A.
Chen, J.
Skoog, L.
Lindblom, A.
author_facet Zelada-Hedman, M.
Børresen-Dale, A. L.
Claro, A.
Chen, J.
Skoog, L.
Lindblom, A.
author_sort Zelada-Hedman, M.
collection PubMed
description To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations were found in any of the patients. We also studied TP53 mutations in tumour DNA from 51 of the same individuals and found mutations in 14%. This is similar to what has been reported in sporadic breast cancer. IMAGES:
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spelling pubmed-22227842009-09-10 Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families. Zelada-Hedman, M. Børresen-Dale, A. L. Claro, A. Chen, J. Skoog, L. Lindblom, A. Br J Cancer Research Article To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations were found in any of the patients. We also studied TP53 mutations in tumour DNA from 51 of the same individuals and found mutations in 14%. This is similar to what has been reported in sporadic breast cancer. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2222784/ /pubmed/9099970 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Zelada-Hedman, M.
Børresen-Dale, A. L.
Claro, A.
Chen, J.
Skoog, L.
Lindblom, A.
Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title_full Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title_fullStr Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title_full_unstemmed Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title_short Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
title_sort screening for tp53 mutations in patients and tumours from 109 swedish breast cancer families.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222784/
https://www.ncbi.nlm.nih.gov/pubmed/9099970
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