p53 gene aberrations in non-small-cell lung carcinomas from a smoking population.

We examined 46 non-small-cell lung carcinomas (NSCLCs) for the presence of p53 mutations in exons 4-9, positive p53 immunostaining and loss of heterozygosity (LOH) in the TP53 locus. p53 mutations were detected in 13 tumour samples (28.3%), whereas overexpression of the p53 protein was found in 30 o...

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Detalles Bibliográficos
Autores principales: Liloglou, T., Ross, H., Prime, W., Donnelly, R. J., Spandidos, D. A., Gosney, J. R., Field, J. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222790/
https://www.ncbi.nlm.nih.gov/pubmed/9099958

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