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Helical Structure and Packing Orientation of the S2 Segment in the Shaker K(+) Channel

Six transmembrane segments, S1–S6, cluster around the central pore-forming region in voltage-gated K(+) channels. To investigate the structural characteristics of the S2 segment in the Shaker K(+) channel, we replaced each residue in S2 singly with tryptophan (or with alanine for the native tryptoph...

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Detalles Bibliográficos
Autores principales: Monks, Stephen A., Needleman, Daniel J., Miller, Christopher
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222899/
https://www.ncbi.nlm.nih.gov/pubmed/10051517