Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

All gammaherpesviruses express homologues of antiapoptotic B-cell lymphoma-2 (BCL-2) to counter the clearance of infected cells by host antiviral defense machineries. To gain insights into the action mechanisms of these viral BCL-2 proteins, we carried out structural and biochemical analyses on the...

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Detalles Bibliográficos
Autores principales: Ku, Bonsu, Woo, Jae-Sung, Liang, Chengyu, Lee, Kwang-Hoon, Hong, Hyang-Suk, E, Xiaofei, Kim, Key-Sun, Jung, Jae U, Oh, Byung-Ha
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222952/
https://www.ncbi.nlm.nih.gov/pubmed/18248095
http://dx.doi.org/10.1371/journal.ppat.0040025

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