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The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na(+) Channels
Lidocaine produces voltage- and use-dependent inhibition of voltage-gated Na(+) channels through preferential binding to channel conformations that are normally populated at depolarized potentials and by slowing the rate of Na(+) channel repriming after depolarizations. It has been proposed that the...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222985/ https://www.ncbi.nlm.nih.gov/pubmed/9874684 |