Overexpression of p53 protein during pancreatitis.

Overexpression of p53 correlates with neoplasia in many cytological specimens. To test the specificity of overexpressed p53 as a tumour marker for the detection of pancreatic cancer, we analysed cytological specimens of pancreatic juice samples from patients with pancreatitis or pancreatic carcinoma...

Descripción completa

Detalles Bibliográficos
Autores principales: Maacke, H., Kessler, A., Schmiegel, W., Roeder, C., Vogel, I., Deppert, W., Kalthoff, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223499/
https://www.ncbi.nlm.nih.gov/pubmed/9166944
_version_ 1782149416659976192
author Maacke, H.
Kessler, A.
Schmiegel, W.
Roeder, C.
Vogel, I.
Deppert, W.
Kalthoff, H.
author_facet Maacke, H.
Kessler, A.
Schmiegel, W.
Roeder, C.
Vogel, I.
Deppert, W.
Kalthoff, H.
author_sort Maacke, H.
collection PubMed
description Overexpression of p53 correlates with neoplasia in many cytological specimens. To test the specificity of overexpressed p53 as a tumour marker for the detection of pancreatic cancer, we analysed cytological specimens of pancreatic juice samples from patients with pancreatitis or pancreatic carcinoma (n = 42) for p53 protein overexpression. p53 protein overexpression was found in 59% of patients with pancreatitis and 67% of patients with pancreatic carcinoma. Thus, the assessment of p53 protein overexpression is not useful in the diagnosis of pancreatic cancer. Overexpressed p53 during pancreatitis appears to be wild-type p53. Overexpression of p53 may result from DNA damage occurring during chronic inflammation. It is well established that p53 can induce apoptosis upon DNA damage. Consequently, we found apoptotic cell death in five out of five tested cytological preparations from patients with pancreatitis as well as in one out of one pancreatic carcinoma specimen. IMAGES:
format Text
id pubmed-2223499
institution National Center for Biotechnology Information
language English
publishDate 1997
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22234992009-09-10 Overexpression of p53 protein during pancreatitis. Maacke, H. Kessler, A. Schmiegel, W. Roeder, C. Vogel, I. Deppert, W. Kalthoff, H. Br J Cancer Research Article Overexpression of p53 correlates with neoplasia in many cytological specimens. To test the specificity of overexpressed p53 as a tumour marker for the detection of pancreatic cancer, we analysed cytological specimens of pancreatic juice samples from patients with pancreatitis or pancreatic carcinoma (n = 42) for p53 protein overexpression. p53 protein overexpression was found in 59% of patients with pancreatitis and 67% of patients with pancreatic carcinoma. Thus, the assessment of p53 protein overexpression is not useful in the diagnosis of pancreatic cancer. Overexpressed p53 during pancreatitis appears to be wild-type p53. Overexpression of p53 may result from DNA damage occurring during chronic inflammation. It is well established that p53 can induce apoptosis upon DNA damage. Consequently, we found apoptotic cell death in five out of five tested cytological preparations from patients with pancreatitis as well as in one out of one pancreatic carcinoma specimen. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2223499/ /pubmed/9166944 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Maacke, H.
Kessler, A.
Schmiegel, W.
Roeder, C.
Vogel, I.
Deppert, W.
Kalthoff, H.
Overexpression of p53 protein during pancreatitis.
title Overexpression of p53 protein during pancreatitis.
title_full Overexpression of p53 protein during pancreatitis.
title_fullStr Overexpression of p53 protein during pancreatitis.
title_full_unstemmed Overexpression of p53 protein during pancreatitis.
title_short Overexpression of p53 protein during pancreatitis.
title_sort overexpression of p53 protein during pancreatitis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223499/
https://www.ncbi.nlm.nih.gov/pubmed/9166944
work_keys_str_mv AT maackeh overexpressionofp53proteinduringpancreatitis
AT kesslera overexpressionofp53proteinduringpancreatitis
AT schmiegelw overexpressionofp53proteinduringpancreatitis
AT roederc overexpressionofp53proteinduringpancreatitis
AT vogeli overexpressionofp53proteinduringpancreatitis
AT deppertw overexpressionofp53proteinduringpancreatitis
AT kalthoffh overexpressionofp53proteinduringpancreatitis

Ejemplares similares