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Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation.

The p16 (MTS1) tumour-suppressor gene is a cyclin-dependent kinase (cdk) inhibitor that decelerates the cell cycle by inactivating the cdks that phosphorylate the retinoblastoma tumour-suppressor gene (Rb) protein (pRb). In cervical cancers, pRb is inactivated by the HPV E7 oncoprotein or by mutatio...

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Detalles Bibliográficos
Autores principales:	Nakao, Y., Yang, X., Yokoyama, M., Ferenczy, A., Tang, S. C., Pater, M. M., Pater, A.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1997
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223509/ https://www.ncbi.nlm.nih.gov/pubmed/9166931

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