Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.

To determine the specificity of neuroendocrine protein gene product (PGP9.5) gene transcripts for detecting micrometastatic neuroblastoma, we have used a highly sensitive polymerase chain reaction (PCR) technique to evaluate expression of this gene in normal blood and bone marrow. While expression o...

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Detalles Bibliográficos
Autores principales: Gilbert, J., Norris, M. D., Marshall, G. M., Haber, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223599/
https://www.ncbi.nlm.nih.gov/pubmed/9192981
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author Gilbert, J.
Norris, M. D.
Marshall, G. M.
Haber, M.
author_facet Gilbert, J.
Norris, M. D.
Marshall, G. M.
Haber, M.
author_sort Gilbert, J.
collection PubMed
description To determine the specificity of neuroendocrine protein gene product (PGP9.5) gene transcripts for detecting micrometastatic neuroblastoma, we have used a highly sensitive polymerase chain reaction (PCR) technique to evaluate expression of this gene in normal blood and bone marrow. While expression of the tyrosine hydroxylase gene was not detected in any normal sample, low-level PGP9.5 expression was detected in eight out of ten blood and seven of 12 marrow samples. PGP9.5 gene transcripts in normal tissues have the potential to interfere with the detection of micrometastatic neuroblastoma. IMAGES:
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spelling pubmed-22235992009-09-10 Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma. Gilbert, J. Norris, M. D. Marshall, G. M. Haber, M. Br J Cancer Research Article To determine the specificity of neuroendocrine protein gene product (PGP9.5) gene transcripts for detecting micrometastatic neuroblastoma, we have used a highly sensitive polymerase chain reaction (PCR) technique to evaluate expression of this gene in normal blood and bone marrow. While expression of the tyrosine hydroxylase gene was not detected in any normal sample, low-level PGP9.5 expression was detected in eight out of ten blood and seven of 12 marrow samples. PGP9.5 gene transcripts in normal tissues have the potential to interfere with the detection of micrometastatic neuroblastoma. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2223599/ /pubmed/9192981 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gilbert, J.
Norris, M. D.
Marshall, G. M.
Haber, M.
Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title_full Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title_fullStr Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title_full_unstemmed Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title_short Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
title_sort low specificity of pgp9.5 expression for detection of micrometastatic neuroblastoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223599/
https://www.ncbi.nlm.nih.gov/pubmed/9192981
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