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Involvement of chromosome 6 in endometrial cancer.

Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple nume...

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Autores principales: Tibiletti, M. G., Bernasconi, B., Taborelli, M., Furlan, D., Fabbri, A., Franchi, M., Taramelli, R., Trubia, M., Capella, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223627/
https://www.ncbi.nlm.nih.gov/pubmed/9192990
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author Tibiletti, M. G.
Bernasconi, B.
Taborelli, M.
Furlan, D.
Fabbri, A.
Franchi, M.
Taramelli, R.
Trubia, M.
Capella, C.
author_facet Tibiletti, M. G.
Bernasconi, B.
Taborelli, M.
Furlan, D.
Fabbri, A.
Franchi, M.
Taramelli, R.
Trubia, M.
Capella, C.
author_sort Tibiletti, M. G.
collection PubMed
description Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural aberrations in the majority of tumours. In contrast, two neoplasms with serous papillary and mixed mullerian morphological features shared multiple complex changes as well as cytogenetic evidence of intratumoral heterogeneity. The most frequent chromosome abnormality in our series of endometrial neoplasms was 6q deletion, which was detected in serous papillary, endometrioid and mixed mullerian tumours. The loss of the 6q region, which is also frequently involved in ovarian carcinoma, suggests a relationship between endometrial and ovarian cancers based on a common histogenesis. IMAGES:
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spelling pubmed-22236272009-09-10 Involvement of chromosome 6 in endometrial cancer. Tibiletti, M. G. Bernasconi, B. Taborelli, M. Furlan, D. Fabbri, A. Franchi, M. Taramelli, R. Trubia, M. Capella, C. Br J Cancer Research Article Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural aberrations in the majority of tumours. In contrast, two neoplasms with serous papillary and mixed mullerian morphological features shared multiple complex changes as well as cytogenetic evidence of intratumoral heterogeneity. The most frequent chromosome abnormality in our series of endometrial neoplasms was 6q deletion, which was detected in serous papillary, endometrioid and mixed mullerian tumours. The loss of the 6q region, which is also frequently involved in ovarian carcinoma, suggests a relationship between endometrial and ovarian cancers based on a common histogenesis. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2223627/ /pubmed/9192990 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tibiletti, M. G.
Bernasconi, B.
Taborelli, M.
Furlan, D.
Fabbri, A.
Franchi, M.
Taramelli, R.
Trubia, M.
Capella, C.
Involvement of chromosome 6 in endometrial cancer.
title Involvement of chromosome 6 in endometrial cancer.
title_full Involvement of chromosome 6 in endometrial cancer.
title_fullStr Involvement of chromosome 6 in endometrial cancer.
title_full_unstemmed Involvement of chromosome 6 in endometrial cancer.
title_short Involvement of chromosome 6 in endometrial cancer.
title_sort involvement of chromosome 6 in endometrial cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223627/
https://www.ncbi.nlm.nih.gov/pubmed/9192990
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