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Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.

Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment o...

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Autores principales: Avril, M. F., Auperin, A., Margulis, A., Gerbaulet, A., Duvillard, P., Benhamou, E., Guillaume, J. C., Chalon, R., Petit, J. Y., Sancho-Garnier, H., Prade, M., Bouzy, J., Chassagne, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223779/
https://www.ncbi.nlm.nih.gov/pubmed/9218740
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author Avril, M. F.
Auperin, A.
Margulis, A.
Gerbaulet, A.
Duvillard, P.
Benhamou, E.
Guillaume, J. C.
Chalon, R.
Petit, J. Y.
Sancho-Garnier, H.
Prade, M.
Bouzy, J.
Chassagne, D.
author_facet Avril, M. F.
Auperin, A.
Margulis, A.
Gerbaulet, A.
Duvillard, P.
Benhamou, E.
Guillaume, J. C.
Chalon, R.
Petit, J. Y.
Sancho-Garnier, H.
Prade, M.
Bouzy, J.
Chassagne, D.
author_sort Avril, M. F.
collection PubMed
description Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of the face measuring less than 4 cm. The primary end point was the failure rate (persistent or recurrent disease) after 4 years of follow-up. The secondary end point was the cosmetic results assessed by the patient, the dermatologist and three persons not involved in the trial. In the course of the trial, 347 patients were treated. Of the 174 patients in the surgery group, 71% had local anaesthesia and 91% frozen section examination. Of the 173 patients in the radiotherapy group, 55% were treated with interstitial brachytherapy, 33% with contactherapy and 12% with conventional radiotherapy. The 4-year actuarial failure rate (95% CI) was 0.7% (0.1-3.9%) in the surgery group compared with 7.5% (4.2-13.1%) in the radiotherapy group (log-rank P = 0.003). The cosmetic results assessed by four of the five judges were significantly better after surgery than after radiotherapy. Eighty-seven per cent of the surgery-treated patients and 69% of the radiation-treated patients considered the cosmetic result as good (P < 0.01). Thus, in the treatment of BCC of the face of less than 4 cm in diameter, surgery should be preferred to radiotherapy.
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spelling pubmed-22237792009-09-10 Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Avril, M. F. Auperin, A. Margulis, A. Gerbaulet, A. Duvillard, P. Benhamou, E. Guillaume, J. C. Chalon, R. Petit, J. Y. Sancho-Garnier, H. Prade, M. Bouzy, J. Chassagne, D. Br J Cancer Research Article Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of the face measuring less than 4 cm. The primary end point was the failure rate (persistent or recurrent disease) after 4 years of follow-up. The secondary end point was the cosmetic results assessed by the patient, the dermatologist and three persons not involved in the trial. In the course of the trial, 347 patients were treated. Of the 174 patients in the surgery group, 71% had local anaesthesia and 91% frozen section examination. Of the 173 patients in the radiotherapy group, 55% were treated with interstitial brachytherapy, 33% with contactherapy and 12% with conventional radiotherapy. The 4-year actuarial failure rate (95% CI) was 0.7% (0.1-3.9%) in the surgery group compared with 7.5% (4.2-13.1%) in the radiotherapy group (log-rank P = 0.003). The cosmetic results assessed by four of the five judges were significantly better after surgery than after radiotherapy. Eighty-seven per cent of the surgery-treated patients and 69% of the radiation-treated patients considered the cosmetic result as good (P < 0.01). Thus, in the treatment of BCC of the face of less than 4 cm in diameter, surgery should be preferred to radiotherapy. Nature Publishing Group 1997 /pmc/articles/PMC2223779/ /pubmed/9218740 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Avril, M. F.
Auperin, A.
Margulis, A.
Gerbaulet, A.
Duvillard, P.
Benhamou, E.
Guillaume, J. C.
Chalon, R.
Petit, J. Y.
Sancho-Garnier, H.
Prade, M.
Bouzy, J.
Chassagne, D.
Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title_full Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title_fullStr Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title_full_unstemmed Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title_short Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.
title_sort basal cell carcinoma of the face: surgery or radiotherapy? results of a randomized study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223779/
https://www.ncbi.nlm.nih.gov/pubmed/9218740
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