Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.

Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 16 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vom...

Descripción completa

Detalles Bibliográficos
Autores principales: Sekine, I., Nishiwaki, Y., Kakinuma, R., Kubota, K., Hojo, F., Matsumoto, T., Ohmatsu, H., Yokozaki, M., Goto, K., Miyamoto, T., Takafuji, J., Kodama, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223781/
https://www.ncbi.nlm.nih.gov/pubmed/9218738
_version_ 1782149438335090688
author Sekine, I.
Nishiwaki, Y.
Kakinuma, R.
Kubota, K.
Hojo, F.
Matsumoto, T.
Ohmatsu, H.
Yokozaki, M.
Goto, K.
Miyamoto, T.
Takafuji, J.
Kodama, T.
author_facet Sekine, I.
Nishiwaki, Y.
Kakinuma, R.
Kubota, K.
Hojo, F.
Matsumoto, T.
Ohmatsu, H.
Yokozaki, M.
Goto, K.
Miyamoto, T.
Takafuji, J.
Kodama, T.
author_sort Sekine, I.
collection PubMed
description Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 16 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vomiting on day 1, and 16 (48%) achieved total control on days 1-5 with acceptable toxicity. High-dose dexamethasone for cisplatin-induced delayed emesis should be further evaluated in a phase III trial.
format Text
id pubmed-2223781
institution National Center for Biotechnology Information
language English
publishDate 1997
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22237812009-09-10 Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413. Sekine, I. Nishiwaki, Y. Kakinuma, R. Kubota, K. Hojo, F. Matsumoto, T. Ohmatsu, H. Yokozaki, M. Goto, K. Miyamoto, T. Takafuji, J. Kodama, T. Br J Cancer Research Article Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 16 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vomiting on day 1, and 16 (48%) achieved total control on days 1-5 with acceptable toxicity. High-dose dexamethasone for cisplatin-induced delayed emesis should be further evaluated in a phase III trial. Nature Publishing Group 1997 /pmc/articles/PMC2223781/ /pubmed/9218738 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sekine, I.
Nishiwaki, Y.
Kakinuma, R.
Kubota, K.
Hojo, F.
Matsumoto, T.
Ohmatsu, H.
Yokozaki, M.
Goto, K.
Miyamoto, T.
Takafuji, J.
Kodama, T.
Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title_full Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title_fullStr Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title_full_unstemmed Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title_short Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--JCOG study 9413.
title_sort phase ii study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis--jcog study 9413.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223781/
https://www.ncbi.nlm.nih.gov/pubmed/9218738
work_keys_str_mv AT sekinei phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT nishiwakiy phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT kakinumar phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT kubotak phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT hojof phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT matsumotot phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT ohmatsuh phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT yokozakim phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT gotok phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT miyamotot phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT takafujij phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413
AT kodamat phaseiistudyofhighdosedexamethasonebasedassociationinacuteanddelayedhighdosecisplatininducedemesisjcogstudy9413

Ejemplares similares