Is a histological section representative of whole tumour vascularity in breast cancer?

The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after in...

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Autores principales: Martin, L., Holcombe, C., Green, B., Leinster, S. J., Winstanley, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223786/
https://www.ncbi.nlm.nih.gov/pubmed/9218730
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author Martin, L.
Holcombe, C.
Green, B.
Leinster, S. J.
Winstanley, J.
author_facet Martin, L.
Holcombe, C.
Green, B.
Leinster, S. J.
Winstanley, J.
author_sort Martin, L.
collection PubMed
description The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with contrast, with that found immunohistochemically. Twenty-one breast angiograms were performed following mastectomy for carcinoma and graded 1-3 for vessel density. Sections (4 microm) from these carcinomas were labelled for endothelial cells using anti-CD34, and the vessel counts were compared with the radiological grades. A significant correlation was found between the densities (P < 0.003, Kruskal-Wallis one-way ANOVA). We therefore conclude that the microvessel density measured in histological sections is representative of whole tumour vascularity. IMAGES:
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spelling pubmed-22237862009-09-10 Is a histological section representative of whole tumour vascularity in breast cancer? Martin, L. Holcombe, C. Green, B. Leinster, S. J. Winstanley, J. Br J Cancer Research Article The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with contrast, with that found immunohistochemically. Twenty-one breast angiograms were performed following mastectomy for carcinoma and graded 1-3 for vessel density. Sections (4 microm) from these carcinomas were labelled for endothelial cells using anti-CD34, and the vessel counts were compared with the radiological grades. A significant correlation was found between the densities (P < 0.003, Kruskal-Wallis one-way ANOVA). We therefore conclude that the microvessel density measured in histological sections is representative of whole tumour vascularity. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2223786/ /pubmed/9218730 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Martin, L.
Holcombe, C.
Green, B.
Leinster, S. J.
Winstanley, J.
Is a histological section representative of whole tumour vascularity in breast cancer?
title Is a histological section representative of whole tumour vascularity in breast cancer?
title_full Is a histological section representative of whole tumour vascularity in breast cancer?
title_fullStr Is a histological section representative of whole tumour vascularity in breast cancer?
title_full_unstemmed Is a histological section representative of whole tumour vascularity in breast cancer?
title_short Is a histological section representative of whole tumour vascularity in breast cancer?
title_sort is a histological section representative of whole tumour vascularity in breast cancer?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223786/
https://www.ncbi.nlm.nih.gov/pubmed/9218730
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