Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.

Microsatellite instability is a form of genetic damage that may be due to defective mismatch repair genes and may be a marker of processes leading to malignancy. We have analysed a series of epithelial hyperplasia of usual type, carcinomas in situ and invasive and metastatic carcinomas from the mamm...

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Autores principales: Dillon, E. K., de Boer, W. B., Papadimitriou, J. M., Turbett, G. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223934/
https://www.ncbi.nlm.nih.gov/pubmed/9231914
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author Dillon, E. K.
de Boer, W. B.
Papadimitriou, J. M.
Turbett, G. R.
author_facet Dillon, E. K.
de Boer, W. B.
Papadimitriou, J. M.
Turbett, G. R.
author_sort Dillon, E. K.
collection PubMed
description Microsatellite instability is a form of genetic damage that may be due to defective mismatch repair genes and may be a marker of processes leading to malignancy. We have analysed a series of epithelial hyperplasia of usual type, carcinomas in situ and invasive and metastatic carcinomas from the mammary gland on the assumption that they represent stages in the evolution of mammary carcinoma. Eight markers on chromosomes 3p, 4q, 9p, 11p, 14q, 17p, 17q and Xq were examined for microsatellite instability and loss of heterozygosity. High rates of loss on chromosomes 17p, 17q and Xq indicate that these chromosomal arms contain genes important in mammary carcinogenesis. The rate of microsatellite instability observed in this study was uniformly low, irrespective of the lesion. This implies that microsatellite instability is not a marker of malignancy in most instances of mammary neoplasia. IMAGES:
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spelling pubmed-22239342009-09-10 Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors. Dillon, E. K. de Boer, W. B. Papadimitriou, J. M. Turbett, G. R. Br J Cancer Research Article Microsatellite instability is a form of genetic damage that may be due to defective mismatch repair genes and may be a marker of processes leading to malignancy. We have analysed a series of epithelial hyperplasia of usual type, carcinomas in situ and invasive and metastatic carcinomas from the mammary gland on the assumption that they represent stages in the evolution of mammary carcinoma. Eight markers on chromosomes 3p, 4q, 9p, 11p, 14q, 17p, 17q and Xq were examined for microsatellite instability and loss of heterozygosity. High rates of loss on chromosomes 17p, 17q and Xq indicate that these chromosomal arms contain genes important in mammary carcinogenesis. The rate of microsatellite instability observed in this study was uniformly low, irrespective of the lesion. This implies that microsatellite instability is not a marker of malignancy in most instances of mammary neoplasia. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2223934/ /pubmed/9231914 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dillon, E. K.
de Boer, W. B.
Papadimitriou, J. M.
Turbett, G. R.
Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title_full Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title_fullStr Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title_full_unstemmed Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title_short Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
title_sort microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223934/
https://www.ncbi.nlm.nih.gov/pubmed/9231914
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