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Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal gangli...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1958
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224329/ https://www.ncbi.nlm.nih.gov/pubmed/13502432 |
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author | Anderson, Everett van Breemen, V. L. |
author_facet | Anderson, Everett van Breemen, V. L. |
author_sort | Anderson, Everett |
collection | PubMed |
description | Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the following in malononitrile-treated animals: 1. The cisternae of the endoplasmic reticulum composing the Nissl bodies appeared to fragment and lose their parallel orientation. 2. The microvesicular components of the Golgi complex appeared to increase in number, and the increase was apparently due to fragmentation of the membrane system of the Golgi complex. 3. The mitochondria enlarged and became pleomorphic, but displayed no alterations of internal structure. The morphological changes may be interpreted as reflections of biochemical alterations. |
format | Text |
id | pubmed-2224329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22243292008-05-01 Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile Anderson, Everett van Breemen, V. L. J Biophys Biochem Cytol Article Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the following in malononitrile-treated animals: 1. The cisternae of the endoplasmic reticulum composing the Nissl bodies appeared to fragment and lose their parallel orientation. 2. The microvesicular components of the Golgi complex appeared to increase in number, and the increase was apparently due to fragmentation of the membrane system of the Golgi complex. 3. The mitochondria enlarged and became pleomorphic, but displayed no alterations of internal structure. The morphological changes may be interpreted as reflections of biochemical alterations. The Rockefeller University Press 1958-01-25 /pmc/articles/PMC2224329/ /pubmed/13502432 Text en Copyright © Copyright, 1958, by The Rockefeller Institute |
spellingShingle | Article Anderson, Everett van Breemen, V. L. Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title | Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title_full | Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title_fullStr | Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title_full_unstemmed | Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title_short | Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile |
title_sort | electron microscopic observations on spinal ganglion cells of rana pipiens after injection of malononitrile |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224329/ https://www.ncbi.nlm.nih.gov/pubmed/13502432 |
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