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Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile

Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal gangli...

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Detalles Bibliográficos
Autores principales: Anderson, Everett, van Breemen, V. L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224329/
https://www.ncbi.nlm.nih.gov/pubmed/13502432
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author Anderson, Everett
van Breemen, V. L.
author_facet Anderson, Everett
van Breemen, V. L.
author_sort Anderson, Everett
collection PubMed
description Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the following in malononitrile-treated animals: 1. The cisternae of the endoplasmic reticulum composing the Nissl bodies appeared to fragment and lose their parallel orientation. 2. The microvesicular components of the Golgi complex appeared to increase in number, and the increase was apparently due to fragmentation of the membrane system of the Golgi complex. 3. The mitochondria enlarged and became pleomorphic, but displayed no alterations of internal structure. The morphological changes may be interpreted as reflections of biochemical alterations.
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spelling pubmed-22243292008-05-01 Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile Anderson, Everett van Breemen, V. L. J Biophys Biochem Cytol Article Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the following in malononitrile-treated animals: 1. The cisternae of the endoplasmic reticulum composing the Nissl bodies appeared to fragment and lose their parallel orientation. 2. The microvesicular components of the Golgi complex appeared to increase in number, and the increase was apparently due to fragmentation of the membrane system of the Golgi complex. 3. The mitochondria enlarged and became pleomorphic, but displayed no alterations of internal structure. The morphological changes may be interpreted as reflections of biochemical alterations. The Rockefeller University Press 1958-01-25 /pmc/articles/PMC2224329/ /pubmed/13502432 Text en Copyright © Copyright, 1958, by The Rockefeller Institute
spellingShingle Article
Anderson, Everett
van Breemen, V. L.
Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title_full Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title_fullStr Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title_full_unstemmed Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title_short Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile
title_sort electron microscopic observations on spinal ganglion cells of rana pipiens after injection of malononitrile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224329/
https://www.ncbi.nlm.nih.gov/pubmed/13502432
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