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Can pill placebo augment cognitive-behavior therapy for panic disorder?

BACKGROUND: In a number of drug and psychotherapy comparative trials, psychotherapy-placebo combination has been assumed to represent psychotherapy. Whether psychotherapy plus pill placebo is the same as psychotherapy alone is an empirical question which however has to date never been examined syste...

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Detalles Bibliográficos
Autores principales: Furukawa, Toshi A, Watanabe, Norio, Omori, Ichiro M, Churchill, Rachel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225396/
https://www.ncbi.nlm.nih.gov/pubmed/18093337
http://dx.doi.org/10.1186/1471-244X-7-73
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author Furukawa, Toshi A
Watanabe, Norio
Omori, Ichiro M
Churchill, Rachel
author_facet Furukawa, Toshi A
Watanabe, Norio
Omori, Ichiro M
Churchill, Rachel
author_sort Furukawa, Toshi A
collection PubMed
description BACKGROUND: In a number of drug and psychotherapy comparative trials, psychotherapy-placebo combination has been assumed to represent psychotherapy. Whether psychotherapy plus pill placebo is the same as psychotherapy alone is an empirical question which however has to date never been examined systematically. METHODS: We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) that directly compared cognitive-behavior therapy (CBT) alone against CBT plus pill placebo in the treatment of panic disorder. RESULTS: Extensive literature search was able to identify three relevant RCTs. At the end of the acute phase treatment, patients who received CBT plus placebo had 26% (95%CI: 2 to 55%) increased chances of responding than those who received CBT alone. At follow-up the difference was no longer statistically significant (22%, 95%CI: -10% to 64%). CONCLUSION: The act of taking a pill placebo may enhance the placebo effect already contained in the effective psychotherapeutic intervention during the acute phase treatment. Theoretically this is an argument against the recently claimed null hypothesis of placebo effect in general and clinically it may point to some further room for enhancing the psychotherapeutic approach for panic disorder.
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spelling pubmed-22253962008-02-03 Can pill placebo augment cognitive-behavior therapy for panic disorder? Furukawa, Toshi A Watanabe, Norio Omori, Ichiro M Churchill, Rachel BMC Psychiatry Research Article BACKGROUND: In a number of drug and psychotherapy comparative trials, psychotherapy-placebo combination has been assumed to represent psychotherapy. Whether psychotherapy plus pill placebo is the same as psychotherapy alone is an empirical question which however has to date never been examined systematically. METHODS: We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) that directly compared cognitive-behavior therapy (CBT) alone against CBT plus pill placebo in the treatment of panic disorder. RESULTS: Extensive literature search was able to identify three relevant RCTs. At the end of the acute phase treatment, patients who received CBT plus placebo had 26% (95%CI: 2 to 55%) increased chances of responding than those who received CBT alone. At follow-up the difference was no longer statistically significant (22%, 95%CI: -10% to 64%). CONCLUSION: The act of taking a pill placebo may enhance the placebo effect already contained in the effective psychotherapeutic intervention during the acute phase treatment. Theoretically this is an argument against the recently claimed null hypothesis of placebo effect in general and clinically it may point to some further room for enhancing the psychotherapeutic approach for panic disorder. BioMed Central 2007-12-20 /pmc/articles/PMC2225396/ /pubmed/18093337 http://dx.doi.org/10.1186/1471-244X-7-73 Text en Copyright © 2007 Furukawa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Furukawa, Toshi A
Watanabe, Norio
Omori, Ichiro M
Churchill, Rachel
Can pill placebo augment cognitive-behavior therapy for panic disorder?
title Can pill placebo augment cognitive-behavior therapy for panic disorder?
title_full Can pill placebo augment cognitive-behavior therapy for panic disorder?
title_fullStr Can pill placebo augment cognitive-behavior therapy for panic disorder?
title_full_unstemmed Can pill placebo augment cognitive-behavior therapy for panic disorder?
title_short Can pill placebo augment cognitive-behavior therapy for panic disorder?
title_sort can pill placebo augment cognitive-behavior therapy for panic disorder?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225396/
https://www.ncbi.nlm.nih.gov/pubmed/18093337
http://dx.doi.org/10.1186/1471-244X-7-73
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