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PPAR Signaling in Placental Development and Function
With the major attention to the pivotal roles of PPARs in diverse aspects of energy metabolism, the essential functions of PPAR [Formula: see text] and PPAR [Formula: see text] in placental development came as a surprise and were often considered a nuisance en route to their genetic analysis. Howeve...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225458/ https://www.ncbi.nlm.nih.gov/pubmed/18288278 http://dx.doi.org/10.1155/2008/142082 |
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author | Barak, Yaacov Sadovsky, Yoel Shalom-Barak, Tali |
author_facet | Barak, Yaacov Sadovsky, Yoel Shalom-Barak, Tali |
author_sort | Barak, Yaacov |
collection | PubMed |
description | With the major attention to the pivotal roles of PPARs in diverse aspects of energy metabolism, the essential functions of PPAR [Formula: see text] and PPAR [Formula: see text] in placental development came as a surprise and were often considered a nuisance en route to their genetic analysis. However, these findings provided an opportune entrée into placental biology. Genetic and pharmacological studies, primarily of knockout animal models and cell culture, uncovered networks of PPAR [Formula: see text] and PPAR [Formula: see text] , their heterodimeric RXR partners, associated transcriptional coactivators, and target genes, that regulate various aspects of placental development and function. These studies furnish both specific information about trophoblasts and the placenta and potential hints about the functions of PPARs in other tissues and cell types. They reveal that the remarkable versatility of PPARs extends beyond the orchestration of metabolism to the regulation of cellular differentiation, tissue development, and trophoblast-specific functions. This information and its implications are the subject of this review. |
format | Text |
id | pubmed-2225458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22254582008-02-14 PPAR Signaling in Placental Development and Function Barak, Yaacov Sadovsky, Yoel Shalom-Barak, Tali PPAR Res Review Article With the major attention to the pivotal roles of PPARs in diverse aspects of energy metabolism, the essential functions of PPAR [Formula: see text] and PPAR [Formula: see text] in placental development came as a surprise and were often considered a nuisance en route to their genetic analysis. However, these findings provided an opportune entrée into placental biology. Genetic and pharmacological studies, primarily of knockout animal models and cell culture, uncovered networks of PPAR [Formula: see text] and PPAR [Formula: see text] , their heterodimeric RXR partners, associated transcriptional coactivators, and target genes, that regulate various aspects of placental development and function. These studies furnish both specific information about trophoblasts and the placenta and potential hints about the functions of PPARs in other tissues and cell types. They reveal that the remarkable versatility of PPARs extends beyond the orchestration of metabolism to the regulation of cellular differentiation, tissue development, and trophoblast-specific functions. This information and its implications are the subject of this review. Hindawi Publishing Corporation 2008 2007-11-25 /pmc/articles/PMC2225458/ /pubmed/18288278 http://dx.doi.org/10.1155/2008/142082 Text en Copyright © 2008 Yaacov Barak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Barak, Yaacov Sadovsky, Yoel Shalom-Barak, Tali PPAR Signaling in Placental Development and Function |
title | PPAR Signaling in Placental Development and Function |
title_full | PPAR Signaling in Placental Development and Function |
title_fullStr | PPAR Signaling in Placental Development and Function |
title_full_unstemmed | PPAR Signaling in Placental Development and Function |
title_short | PPAR Signaling in Placental Development and Function |
title_sort | ppar signaling in placental development and function |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225458/ https://www.ncbi.nlm.nih.gov/pubmed/18288278 http://dx.doi.org/10.1155/2008/142082 |
work_keys_str_mv | AT barakyaacov pparsignalinginplacentaldevelopmentandfunction AT sadovskyyoel pparsignalinginplacentaldevelopmentandfunction AT shalombaraktali pparsignalinginplacentaldevelopmentandfunction |