Cargando…

PPAR- [Formula: see text] in the Cardiovascular System

Peroxisome proliferator-activated receptor- [Formula: see text] (PPAR- [Formula: see text]), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular d...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Sheng Zhong, Ivashchenko, Christine Y., Usher, Michael G., Mortensen, Richard M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225467/
https://www.ncbi.nlm.nih.gov/pubmed/18288291
http://dx.doi.org/10.1155/2008/745804
_version_ 1782149661857939456
author Duan, Sheng Zhong
Ivashchenko, Christine Y.
Usher, Michael G.
Mortensen, Richard M.
author_facet Duan, Sheng Zhong
Ivashchenko, Christine Y.
Usher, Michael G.
Mortensen, Richard M.
author_sort Duan, Sheng Zhong
collection PubMed
description Peroxisome proliferator-activated receptor- [Formula: see text] (PPAR- [Formula: see text]), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis. PPAR- [Formula: see text] agonists, the thiazolidinediones (TZDs), increase insulin sensitivity, lower blood glucose, decrease circulating free fatty acids and triglycerides, lower blood pressure, reduce inflammatory markers, and reduce atherosclerosis in insulin-resistant patients and animal models. Human genetic studies on PPAR- [Formula: see text] have revealed that functional changes in this nuclear receptor are associated with CVD. Recent controversial clinical studies raise the question of deleterious action of PPAR- [Formula: see text] agonists on the cardiovascular system. These complex interactions of metabolic responsive factors and cardiovascular disease promise to be important areas of focus for the future.
format Text
id pubmed-2225467
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-22254672008-02-14 PPAR- [Formula: see text] in the Cardiovascular System Duan, Sheng Zhong Ivashchenko, Christine Y. Usher, Michael G. Mortensen, Richard M. PPAR Res Review Article Peroxisome proliferator-activated receptor- [Formula: see text] (PPAR- [Formula: see text]), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis. PPAR- [Formula: see text] agonists, the thiazolidinediones (TZDs), increase insulin sensitivity, lower blood glucose, decrease circulating free fatty acids and triglycerides, lower blood pressure, reduce inflammatory markers, and reduce atherosclerosis in insulin-resistant patients and animal models. Human genetic studies on PPAR- [Formula: see text] have revealed that functional changes in this nuclear receptor are associated with CVD. Recent controversial clinical studies raise the question of deleterious action of PPAR- [Formula: see text] agonists on the cardiovascular system. These complex interactions of metabolic responsive factors and cardiovascular disease promise to be important areas of focus for the future. Hindawi Publishing Corporation 2008 2007-12-06 /pmc/articles/PMC2225467/ /pubmed/18288291 http://dx.doi.org/10.1155/2008/745804 Text en Copyright © 2008 Sheng Zhong Duan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Duan, Sheng Zhong
Ivashchenko, Christine Y.
Usher, Michael G.
Mortensen, Richard M.
PPAR- [Formula: see text] in the Cardiovascular System
title PPAR- [Formula: see text] in the Cardiovascular System
title_full PPAR- [Formula: see text] in the Cardiovascular System
title_fullStr PPAR- [Formula: see text] in the Cardiovascular System
title_full_unstemmed PPAR- [Formula: see text] in the Cardiovascular System
title_short PPAR- [Formula: see text] in the Cardiovascular System
title_sort ppar- [formula: see text] in the cardiovascular system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225467/
https://www.ncbi.nlm.nih.gov/pubmed/18288291
http://dx.doi.org/10.1155/2008/745804
work_keys_str_mv AT duanshengzhong pparformulaseetextinthecardiovascularsystem
AT ivashchenkochristiney pparformulaseetextinthecardiovascularsystem
AT ushermichaelg pparformulaseetextinthecardiovascularsystem
AT mortensenrichardm pparformulaseetextinthecardiovascularsystem