DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]

Two novel cobalt(III) pyridine complexes (1) [Formula: see text] and (2) [Formula: see text] (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectrosco...

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Detalles Bibliográficos
Autores principales: Nagababu, Penumaka, Kumar, D. Aravind, Reddy, Kotha Laxma, Kumar, K. Ashwini, Mustafa, Md. B., Shilpa, Mynam, Satyanarayana, S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225500/
https://www.ncbi.nlm.nih.gov/pubmed/18274660
http://dx.doi.org/10.1155/2008/275084
Descripción
Sumario:Two novel cobalt(III) pyridine complexes (1) [Formula: see text] and (2) [Formula: see text] (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity.

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