DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]

Two novel cobalt(III) pyridine complexes (1) [Formula: see text] and (2) [Formula: see text] (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectrosco...

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Autores principales: Nagababu, Penumaka, Kumar, D. Aravind, Reddy, Kotha Laxma, Kumar, K. Ashwini, Mustafa, Md. B., Shilpa, Mynam, Satyanarayana, S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225500/
https://www.ncbi.nlm.nih.gov/pubmed/18274660
http://dx.doi.org/10.1155/2008/275084
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author Nagababu, Penumaka
Kumar, D. Aravind
Reddy, Kotha Laxma
Kumar, K. Ashwini
Mustafa, Md. B.
Shilpa, Mynam
Satyanarayana, S.
author_facet Nagababu, Penumaka
Kumar, D. Aravind
Reddy, Kotha Laxma
Kumar, K. Ashwini
Mustafa, Md. B.
Shilpa, Mynam
Satyanarayana, S.
author_sort Nagababu, Penumaka
collection PubMed
description Two novel cobalt(III) pyridine complexes (1) [Formula: see text] and (2) [Formula: see text] (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity.
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spelling pubmed-22255002008-02-14 DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text] Nagababu, Penumaka Kumar, D. Aravind Reddy, Kotha Laxma Kumar, K. Ashwini Mustafa, Md. B. Shilpa, Mynam Satyanarayana, S. Met Based Drugs Research Article Two novel cobalt(III) pyridine complexes (1) [Formula: see text] and (2) [Formula: see text] (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity. Hindawi Publishing Corporation 2008 2007-10-01 /pmc/articles/PMC2225500/ /pubmed/18274660 http://dx.doi.org/10.1155/2008/275084 Text en Copyright © 2008 Penumaka Nagababu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nagababu, Penumaka
Kumar, D. Aravind
Reddy, Kotha Laxma
Kumar, K. Ashwini
Mustafa, Md. B.
Shilpa, Mynam
Satyanarayana, S.
DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title_full DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title_fullStr DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title_full_unstemmed DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title_short DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Formula: see text] and [Formula: see text]
title_sort dna binding and photocleavage studies of cobalt(iii) ethylenediamine pyridine complexes: [formula: see text] and [formula: see text]
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225500/
https://www.ncbi.nlm.nih.gov/pubmed/18274660
http://dx.doi.org/10.1155/2008/275084
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